[
  {
    "field_id": "connected_people_n",
    "public_label": "Connected people",
    "definition": "Number of connected people represented in a clinical-area coverage row.",
    "unit_of_analysis": "clinical area",
    "data_type": "whole number",
    "allowed_values": "0 or greater",
    "missing_states": "not applicable",
    "allowed_source_types": "connected ASH1L dataset",
    "eligible_denominator": "connected people"
  },
  {
    "field_id": "clinical_area",
    "public_label": "Clinical area",
    "definition": "Plain-language name of one of the 15 public clinical areas.",
    "unit_of_analysis": "clinical area",
    "data_type": "text",
    "allowed_values": "one named clinical area",
    "missing_states": "not applicable",
    "allowed_source_types": "ASH1L Clinical Area Guide",
    "eligible_denominator": "all clinical-area rows"
  },
  {
    "field_id": "information_available_n",
    "public_label": "Information available",
    "definition": "Number of connected people for whom the available sources address the clinical area in any supported information state.",
    "unit_of_analysis": "clinical area",
    "data_type": "whole number",
    "allowed_values": "0 through connected_people_n",
    "missing_states": "not applicable",
    "allowed_source_types": "connected ASH1L dataset",
    "eligible_denominator": "connected people"
  },
  {
    "field_id": "area_not_addressed_n",
    "public_label": "Area not addressed",
    "definition": "Number of connected people whose available sources do not address the clinical area; this is missing information, not absence of a feature.",
    "unit_of_analysis": "clinical area",
    "data_type": "whole number",
    "allowed_values": "0 through connected_people_n",
    "missing_states": "not applicable",
    "allowed_source_types": "connected ASH1L dataset",
    "eligible_denominator": "connected people"
  },
  {
    "field_id": "original_source_documents_available_n",
    "public_label": "Original source documents available",
    "definition": "Number of connected people with an original clinical or laboratory source document addressing the broad clinical area.",
    "unit_of_analysis": "clinical area",
    "data_type": "whole number",
    "allowed_values": "0 through information_available_n",
    "missing_states": "not applicable",
    "allowed_source_types": "connected ASH1L dataset",
    "eligible_denominator": "connected people"
  },
  {
    "field_id": "study_number",
    "public_label": "Study number",
    "definition": "Reader-facing number for one published human study source.",
    "unit_of_analysis": "study",
    "data_type": "whole number",
    "allowed_values": "1 through 10",
    "missing_states": "not applicable",
    "allowed_source_types": "cited publication",
    "eligible_denominator": "human study sources"
  },
  {
    "field_id": "feature_number",
    "public_label": "Feature number",
    "definition": "Reader-facing number for a harmonized phenotype feature while preserving the source term separately.",
    "unit_of_analysis": "feature",
    "data_type": "whole number",
    "allowed_values": "1 through 34",
    "missing_states": "not applicable",
    "allowed_source_types": "cited publication and public feature dictionary",
    "eligible_denominator": "human phenotype results"
  },
  {
    "field_id": "study_n",
    "public_label": "Study size",
    "definition": "Total number of participants described in the named study group.",
    "unit_of_analysis": "study",
    "data_type": "whole number",
    "allowed_values": "0 or greater",
    "missing_states": "not reported when the source does not define it",
    "allowed_source_types": "cited publication",
    "eligible_denominator": "named study group"
  },
  {
    "field_id": "eligible_ash1l_n",
    "public_label": "Eligible ASH1L participants",
    "definition": "Number of participants with an ASH1L result who are eligible for the study-level matrix under the stated source rule.",
    "unit_of_analysis": "study",
    "data_type": "whole number",
    "allowed_values": "0 through study_n",
    "missing_states": "not reported when the source does not define it",
    "allowed_source_types": "cited publication",
    "eligible_denominator": "named study group"
  },
  {
    "field_id": "independent_family_n",
    "public_label": "Independent families",
    "definition": "Number of independent families represented when the source provides enough information to distinguish family structure. This is not interchangeable with participant count.",
    "unit_of_analysis": "study",
    "data_type": "whole number",
    "allowed_values": "0 or greater",
    "missing_states": "not reported when the source does not define it",
    "allowed_source_types": "cited publication",
    "eligible_denominator": "named study group"
  },
  {
    "field_id": "molecular_class",
    "public_label": "Molecular context",
    "definition": "Reader-facing summary of the molecular class or association context for the named study group.",
    "unit_of_analysis": "study",
    "data_type": "text",
    "allowed_values": "LoF / truncating; Missense; Missense VUS; Mixed; Association and rare-variant context; Common-variant association",
    "missing_states": "not reported",
    "allowed_source_types": "cited publication",
    "eligible_denominator": "named study group"
  },
  {
    "field_id": "eligible_n",
    "public_label": "Eligible denominator",
    "definition": "Number of people eligible for the feature assessment under the study-specific rule.",
    "unit_of_analysis": "study × feature",
    "data_type": "whole number",
    "allowed_values": "0 or greater",
    "missing_states": "not reported when the source does not define it",
    "allowed_source_types": "cited publication",
    "eligible_denominator": "study-specific eligible group"
  },
  {
    "field_id": "assessed_n",
    "public_label": "Assessed denominator",
    "definition": "Number of eligible people for whom the source reports an assessment of the feature.",
    "unit_of_analysis": "study × feature",
    "data_type": "whole number",
    "allowed_values": "0 through eligible_n",
    "missing_states": "not reported when the source does not define it",
    "allowed_source_types": "cited publication",
    "eligible_denominator": "study-specific eligible group"
  },
  {
    "field_id": "positive_n",
    "public_label": "Positive count",
    "definition": "Number of assessed people reported as having the feature under the source-specific definition.",
    "unit_of_analysis": "study × feature",
    "data_type": "whole number",
    "allowed_values": "0 through assessed_n",
    "missing_states": "not reported when the source does not define it",
    "allowed_source_types": "cited publication",
    "eligible_denominator": "assessed_n"
  },
  {
    "field_id": "negative_n",
    "public_label": "Negative count",
    "definition": "Number of assessed people explicitly reported as not having the feature; a blank value is never converted to negative.",
    "unit_of_analysis": "study × feature",
    "data_type": "whole number",
    "allowed_values": "0 through assessed_n",
    "missing_states": "not reported when the source does not define it",
    "allowed_source_types": "cited publication",
    "eligible_denominator": "assessed_n"
  },
  {
    "field_id": "missing_n",
    "public_label": "Missing count",
    "definition": "Number of eligible people without a reported assessment when the source supports this calculation.",
    "unit_of_analysis": "study × feature",
    "data_type": "whole number",
    "allowed_values": "0 through eligible_n",
    "missing_states": "not reported when it cannot be calculated",
    "allowed_source_types": "cited publication",
    "eligible_denominator": "eligible_n"
  },
  {
    "field_id": "assessment_status",
    "public_label": "Assessment status",
    "definition": "States whether the feature was assessed systematically, reported selectively, or measured only in a tested subset.",
    "unit_of_analysis": "study × feature",
    "data_type": "text",
    "allowed_values": "Feature assessed systematically; Feature reported selectively; Only a tested subset of participants is reported",
    "missing_states": "not reported",
    "allowed_source_types": "cited publication",
    "eligible_denominator": "study-specific result"
  },
  {
    "field_id": "denominator_closure",
    "public_label": "Denominator closure",
    "definition": "States whether the published counts account for all eligible participants or only an assessed subset.",
    "unit_of_analysis": "study × feature",
    "data_type": "text",
    "allowed_values": "All eligible participants accounted for; Eligible participants are missing; Only an assessed subset of participants is reported",
    "missing_states": "not reported",
    "allowed_source_types": "cited publication",
    "eligible_denominator": "study-specific result"
  },
  {
    "field_id": "missingness_state",
    "public_label": "Missingness statement",
    "definition": "Plain-language statement of how many eligible participants do not have a reportable value for the result.",
    "unit_of_analysis": "study × feature",
    "data_type": "text",
    "allowed_values": "No eligible participant is missing from this result; or a stated number of eligible participants without a reportable value",
    "missing_states": "not reported",
    "allowed_source_types": "cited publication",
    "eligible_denominator": "study-specific result"
  },
  {
    "field_id": "harmonization",
    "public_label": "Feature harmonization",
    "definition": "States whether the source term is an exact match to the public feature definition or was combined into a broader composite feature.",
    "unit_of_analysis": "study × feature",
    "data_type": "text",
    "allowed_values": "exact; composite",
    "missing_states": "not reported",
    "allowed_source_types": "cited publication and public feature definition",
    "eligible_denominator": "study-specific result"
  },
  {
    "field_id": "denominator_basis",
    "public_label": "Denominator basis",
    "definition": "Source-specific explanation of who was eligible and who was assessed for the result.",
    "unit_of_analysis": "study × feature",
    "data_type": "text",
    "allowed_values": "source-specific definition",
    "missing_states": "not reported",
    "allowed_source_types": "cited publication",
    "eligible_denominator": "study-specific result"
  },
  {
    "field_id": "source_detail_status",
    "public_label": "Source detail status",
    "definition": "States whether the result comes from the primary source or has a documented disagreement between source sections.",
    "unit_of_analysis": "study × feature",
    "data_type": "text",
    "allowed_values": "Primary source; Primary text with source sections disagreeing",
    "missing_states": "not reported",
    "allowed_source_types": "cited publication",
    "eligible_denominator": "study-specific result"
  },
  {
    "field_id": "included_in_study_specific_results",
    "public_label": "Included in study-specific results",
    "definition": "States whether the result can be used in the study-specific comparison. False preserves a documented disagreement between source sections without treating that row as a resolved result.",
    "unit_of_analysis": "study × feature",
    "data_type": "true or false",
    "allowed_values": "true or false",
    "missing_states": "not applicable",
    "allowed_source_types": "cited publication",
    "eligible_denominator": "study-specific result"
  },
  {
    "field_id": "positive_only_n",
    "public_label": "Reported finding only",
    "definition": "Number of connected people whose available information reports at least one finding in the broad clinical area without an explicitly normal or unresolved item in that area.",
    "unit_of_analysis": "clinical area",
    "data_type": "whole number",
    "allowed_values": "0 through information_available_n",
    "missing_states": "not applicable",
    "allowed_source_types": "available family information and original source documents",
    "eligible_denominator": "connected people with information in the area"
  },
  {
    "field_id": "positive_and_negative_or_unresolved_n",
    "public_label": "Reported finding plus normal or unresolved information",
    "definition": "Number of connected people whose available information contains a reported finding plus either an explicitly normal result or an unresolved observation in the same broad clinical area.",
    "unit_of_analysis": "clinical area",
    "data_type": "whole number",
    "allowed_values": "0 through information_available_n",
    "missing_states": "not applicable",
    "allowed_source_types": "available family information and original source documents",
    "eligible_denominator": "connected people with information in the area"
  },
  {
    "field_id": "explicit_negative_only_n",
    "public_label": "Only explicitly normal results",
    "definition": "Number of connected people whose available information records an explicitly normal or negative result in the broad clinical area without a reported finding there.",
    "unit_of_analysis": "clinical area",
    "data_type": "whole number",
    "allowed_values": "0 through information_available_n",
    "missing_states": "not applicable",
    "allowed_source_types": "available family information and original source documents",
    "eligible_denominator": "connected people with information in the area"
  },
  {
    "field_id": "unresolved_without_positive_n",
    "public_label": "Only unresolved information",
    "definition": "Number of connected people whose available information contains an unresolved observation in the broad clinical area and no reported finding there.",
    "unit_of_analysis": "clinical area",
    "data_type": "whole number",
    "allowed_values": "0 through information_available_n",
    "missing_states": "not applicable",
    "allowed_source_types": "available family information and original source documents",
    "eligible_denominator": "connected people with information in the area"
  },
  {
    "field_id": "other_information_available_n",
    "public_label": "Other information available",
    "definition": "Number of connected people with information in the broad clinical area that does not fit the four stated finding, normal, or unresolved combinations.",
    "unit_of_analysis": "clinical area",
    "data_type": "whole number",
    "allowed_values": "0 through information_available_n",
    "missing_states": "not applicable",
    "allowed_source_types": "available family information and original source documents",
    "eligible_denominator": "connected people with information in the area"
  }
]