COMPLETE CITATION
Citation and identifiers
Yoon E, Song JJ. “Caf1 regulates the histone methyltransferase activity of Ash1 by sensing unmodified histone H3.” Epigenetics & Chromatin. 16:15 · doi:10.1186/s13072-023-00487-6.
- PubMed ID
- 37118845 ↗
RESEARCH QUESTION
How does Caf1 sensing of unmodified histone H3 regulate the H3K36 methyltransferase activity of the Ash1 complex?
Biochemical experiments place Caf1 near the Ash1 reader-domain region and show regulation through H3K4-state sensing, without testing human variants, dosage, neurodevelopment, or treatment response.
INTERPRETATION BOUNDARY
Read the finding and limit together.
What this study supports
Biochemical work showed that Caf1 binds the Ash1 complex near its reader-domain region, senses unmodified H3K4, and regulates H3K36 methyltransferase activity.
What it cannot establish
Mechanistic protein-complex and chromatin evidence. It does not test human ASH1L variants, neurodevelopmental phenotypes, gene dosage, or treatment response.
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