COMPLETE CITATION
Citation and identifiers
Gao Y, Duque-Wilckens N, Aljazi MB, et al.. “Loss of histone methyltransferase ASH1L in the developing mouse brain causes autistic-like behaviors.” Communications Biology. 4:756 · doi:10.1038/s42003-021-02282-z.
- PubMed ID
- 34145365 ↗
RESEARCH QUESTION
How does developmental neural-lineage loss of Ash1l affect cortical development, myelination, cognition, and behavior in mice?
The neural-lineage mouse deletion links Ash1l loss to several developmental brain and behavioral outcomes, while its broad Nestin-lineage design cannot assign them to one cell class or to humans.
INTERPRETATION BOUNDARY
Read the finding and limit together.
What this study supports
He Lab developmental neural-lineage deletion supports effects on cortical development, myelination, cognition, and behavior.
What it cannot establish
Nestin-lineage mouse deletion includes multiple neural cell classes and does not isolate a mature astrocyte, microglial, or human mechanism.
OPEN THE STUDY