COMPLETE CITATION
Citation and identifiers
Wu Y, Gao Y, Aljazi MB, He J. “Vorinostat, a histone deacetylase inhibitor, ameliorates sociability and cognitive memory in an Ash1L-deletion-induced ASD/ID mouse model.” Neuroscience Letters. 759:136016 · doi:10.1016/j.neulet.2021.136016.
- PubMed ID
- 34509565 ↗
RESEARCH QUESTION
Can postnatal vorinostat improve selected sociability and cognitive-memory measures in an Ash1l-deletion mouse model?
The reported rescue is limited to selected outcomes in a mouse model and does not establish vorinostat efficacy, safety, timing, or clinical use in people.
INTERPRETATION BOUNDARY
Read the finding and limit together.
What this study supports
He Lab mouse study reports postnatal vorinostat-associated improvement in selected social and memory measures.
What it cannot establish
Preclinical mouse pharmacology. It does not establish human efficacy, safety, timing, or clinical use of vorinostat.
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