COMPLETE CITATION
Citation and identifiers
Maritz C, Khaleghi R, Yancoskie MN, et al.. “ASH1L-MRG15 methyltransferase deposits H3K4me3 and FACT for damage verification in nucleotide excision repair.” Nature Communications. 14:3892 · doi:10.1038/s41467-023-39635-7.
- PubMed ID
- 37393406 ↗
RESEARCH QUESTION
How do ASH1L and MRG15 support lesion verification and global-genome nucleotide-excision repair after UV exposure in cultured human cells?
The cultured-cell study links ASH1L–MRG15 to lesion-associated H3K4me3, XPC redistribution, repair-factor engagement, and FACT recruitment without establishing a clinical DNA-repair disorder or screening indication.
INTERPRETATION BOUNDARY
Read the finding and limit together.
What this study supports
In cultured human cells exposed to UV, ASH1L and MRG15 supported lesion-associated H3K4me3, XPC redistribution, downstream repair-factor engagement, and FACT recruitment in global-genome nucleotide-excision repair.
What it cannot establish
This is a defined cultured-cell UV-repair context. It does not establish a generalized DNA-repair disorder, genome instability, UV sensitivity, or a clinical screening indication in people with ASH1L-related neurodevelopmental disorder.
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