COMPLETE CITATION
Citation and identifiers
Zhu JY, Liu C, Huang X, et al.. “H3K36 Di-Methylation Marks, Mediated by Ash1 in Complex with Caf1-55 and MRG15, Are Required during Drosophila Heart Development.” Journal of Cardiovascular Development and Disease. 10(7):307 · doi:10.3390/jcdd10070307.
- PubMed ID
- 37504562 ↗
RESEARCH QUESTION
Are Ash1-dependent H3K36me2 and its Caf1-55 and MRG15 complex partners required for normal heart development and function in Drosophila?
The fly study supports a cardiac-development mechanism involving the Ash1 ortholog and its complex partners but cannot establish human cardiac manifestations or screening needs.
INTERPRETATION BOUNDARY
Read the finding and limit together.
What this study supports
In Drosophila, Ash1-dependent H3K36me2 and its Caf1-55 and MRG15 complex partners were required for normal cardiac development and function.
What it cannot establish
Distal species evidence involving the fly Ash1 ortholog. It supports a developmental tissue mechanism but does not establish a human cardiac phenotype or screening indication.
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