COMPLETE CITATION
Citation and identifiers
Yan Y, Tian M, Li M, et al.. “ASH1L haploinsufficiency results in autistic-like phenotypes in mice and links Eph receptor gene to autism spectrum disorder.” Neuron. 110(7):1156–1172.e9 · doi:10.1016/j.neuron.2021.12.035.
- PubMed ID
- 35081333 ↗
RESEARCH QUESTION
Does Ash1l haploinsufficiency disrupt EphA7-dependent synaptic refinement in association with autism-like phenotypes in mice?
The mouse study connects Ash1l haploinsufficiency, developmental and behavioral phenotypes, and an EphA7-linked synaptic pathway without validating a human biomarker or treatment target.
INTERPRETATION BOUNDARY
Read the finding and limit together.
What this study supports
Connects Ash1l haploinsufficiency to developmental and behavioral phenotypes and implicates EphA7-dependent synaptic refinement in mice.
What it cannot establish
Model-supported pathway, not a validated human biomarker or treatment target.
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