COMPLETE CITATION
Citation and identifiers
Gao Y, Aljazi MB, He J. “Neural hyperactivity is a core pathophysiological change induced by deletion of an autism risk gene Ash1l in the mouse brain.” Frontiers in Behavioral Neuroscience. 16:873466 · doi:10.3389/fnbeh.2022.873466.
- PubMed ID
- 35449559 ↗
RESEARCH QUESTION
Does Ash1l deletion produce neural hyperactivity alongside altered sleep, metabolism, locomotion, and seizure threshold in mice?
The study reports increased regional neuronal activity with behavioral and physiological changes in Ash1l-deficient mice, which does not establish the same state mechanism or endpoint in people.
INTERPRETATION BOUNDARY
Read the finding and limit together.
What this study supports
He Lab work reports locomotor and metabolic hyperactivity, disturbed sleep, lower induced-seizure threshold, and increased regional neuronal activity in Ash1l-deficient mice.
What it cannot establish
Mouse behavioral and physiological phenotypes do not establish a corresponding human state mechanism or clinical endpoint.
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