COMPLETE CITATION
Citation and identifiers
Zhang T, Ren T, Lin H, et al.. “ASH1L contributes to oocyte apoptosis by regulating DNA damage.” American Journal of Physiology–Cell Physiology. 323(4):C1264–C1273 · doi:10.1152/ajpcell.00196.2022.
- PubMed ID
- 36094439 ↗
RESEARCH QUESTION
Does Ash1l overexpression alter DNA-damage signaling and oocyte survival in mouse fetal ovaries?
The experiment links Ash1l overexpression to altered double-strand-break repair signaling and increased oocyte apoptosis, a perturbation direction that cannot establish fertility risk from ASH1L haploinsufficiency.
INTERPRETATION BOUNDARY
Read the finding and limit together.
What this study supports
Ash1l overexpression in mouse fetal ovaries altered DNA double-strand-break repair signaling and increased oocyte apoptosis in the tested system.
What it cannot establish
This is an overexpression experiment—the opposite perturbation direction from haploinsufficiency—and does not establish fertility risk in people with ASH1L-related disorder.
OPEN THE STUDY