COMPLETE CITATION
Citation and identifiers
Terceros A, Chen C, Harada Y, et al.. “Thalamocortical transcriptional gates coordinate memory stabilization.” Nature. 649:1254–1263 · doi:10.1038/s41586-025-09774-6.
- PubMed ID
- 41299170 ↗
RESEARCH QUESTION
Is ASH1L required for late stabilization, rather than initial formation, of selected memories in the tested mouse thalamocortical circuit?
Targeted mouse-circuit perturbation placed ASH1L late in a CAMTA1–TCF4–ASH1L cascade that maintained selected memories over weeks without defining human memory trajectories.
INTERPRETATION BOUNDARY
Read the finding and limit together.
What this study supports
Targeted perturbation in a mouse memory circuit identified a sequential CAMTA1–TCF4–ASH1L transcriptional cascade. In that task, ASH1L was required later to maintain selected memories over weeks rather than for initial memory formation.
What it cannot establish
Circuit- and task-specific mouse evidence. It separates memory stabilization from acquisition experimentally but does not define an individual human memory profile or prove progressive decline.
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