COMPLETE CITATION
Citation and identifiers
Pruitt A, Yang L, Lee S, et al.. “Estradiol modulates neuronal network hyperexcitability in select NDD risk genes.” bioRxiv. 2026.02.18.706588 · doi:10.64898/2026.02.18.706588.
- PubMed ID
- 41757108 ↗
RESEARCH QUESTION
Does estradiol alter transcriptional, network-bursting, sleep-wake, or visual-startle phenotypes after ASH1L perturbation in the tested neuronal and zebrafish models?
This non-peer-reviewed dual-system screen measured ASH1L-linked responses to estradiol in human induced neurons and larval zebrafish but did not test clinical benefit, safety, dose, or timing.
INTERPRETATION BOUNDARY
Read the finding and limit together.
What this study supports
A Yale-led dual-system screen reported ASH1L responses across gene expression and network bursting in human induced neurons and sleep-wake and visual-startle measures in larval zebrafish.
What it cannot establish
Non-peer-reviewed model-system evidence. It does not establish benefit, safety, dose, timing, or treatment guidance for people with ASH1L-related disorder.
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