COMPLETE CITATION
Citation and identifiers
Liu S, Tian M, He F, et al.. “Mutations in ASH1L confer susceptibility to Tourette syndrome.” Molecular Psychiatry. 25(2):476–490 · doi:10.1038/s41380-019-0560-8.
- PubMed ID
- 31673123 ↗
RESEARCH QUESTION
Do human genetic and functional data support ASH1L as a susceptibility gene for Tourette syndrome?
The study addresses Tourette-syndrome susceptibility using human and follow-up model evidence, an ascertainment context distinct from ASH1L haploinsufficiency-related neurodevelopmental disorder.
INTERPRETATION BOUNDARY
Read the finding and limit together.
What this study supports
Human genetic analysis with functional and animal-model follow-up supporting ASH1L as a Tourette-susceptibility gene.
What it cannot establish
Tourette-susceptibility findings are a distinct ascertainment and disease context from ASH1L haploinsufficiency-related NDD.
OPEN THE STUDY