COMPLETE CITATION
Citation and identifiers
Lee Y, Yoon E, Cho S, et al.. “Structural Basis of MRG15-Mediated Activation of the ASH1L Histone Methyltransferase by Releasing an Autoinhibitory Loop.” Structure. 27(5):846–852.e3 · doi:10.1016/j.str.2019.01.016.
- PubMed ID
- 30827841 ↗
RESEARCH QUESTION
How does MRG15 binding release ASH1L autoinhibition and activate H3K36 methyltransferase activity?
The purified-complex structure and biochemistry explain catalytic activation by MRG15 but do not establish the consequence of an individual human variant.
INTERPRETATION BOUNDARY
Read the finding and limit together.
What this study supports
Structural work defined how MRG15 binding releases ASH1L catalytic autoinhibition and activates its H3K36 methyltransferase function.
What it cannot establish
Purified-complex structure and biochemistry do not establish the functional consequence of an individual human variant or a clinical severity relationship.
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