COMPLETE CITATION
Citation and identifiers
Hou P, Lee JS, Zhao R, et al.. “Structural insights into stimulation of Ash1L's H3K36 methyltransferase activity through Mrg15 binding.” Structure. 27(5):837–845.e3 · doi:10.1016/j.str.2019.01.015.
- PubMed ID
- 30827843 ↗
RESEARCH QUESTION
What structural features explain stimulation of Ash1L H3K36 methyltransferase activity through Mrg15 binding?
This structural analysis defines the Mrg15-associated activation architecture of the catalytic region without functioning as a clinical phenotype or variant-severity assay.
INTERPRETATION BOUNDARY
Read the finding and limit together.
What this study supports
Defines MRG15-associated activation and the autoinhibitory architecture of the ASH1L catalytic region.
What it cannot establish
Structural complex evidence is not a clinical phenotype or variant-severity assay.
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