COMPLETE CITATION
Citation and identifiers
Castiglioni I, Caccia R, Garcia-Manteiga JM, et al.. “The Trithorax protein Ash1L promotes myoblast fusion by activating Cdon expression.” Nature Communications. 9:5026 · doi:10.1038/s41467-018-07313-8.
- PubMed ID
- 30487570 ↗
RESEARCH QUESTION
How does Ash1l promote myoblast fusion and muscle regeneration through regulation of Cdon?
The mouse muscle and myoblast findings support a direct role in fusion and regeneration but do not establish a primary human myopathy or explain every motor-related feature.
INTERPRETATION BOUNDARY
Read the finding and limit together.
What this study supports
In mouse muscle and myoblast systems, Ash1l opposed Polycomb repression at selected myogenic genes, activated Cdon, and supported myoblast fusion during formation and regeneration.
What it cannot establish
Direct muscle-lineage evidence, but not proof of a primary human myopathy or an explanation for every tone, gait, fatigue, or recovery finding.
OPEN THE STUDY