COMPLETE CITATION
Citation and identifiers
Li G, Ye Z, Shi C, et al.. “The histone methyltransferase Ash1l is required for epidermal homeostasis in mice.” Scientific Reports. 7:45401 · doi:10.1038/srep45401.
- PubMed ID
- 28374742 ↗
RESEARCH QUESTION
Is Ash1l required for epidermal differentiation, proliferation, homeostasis, and wound repair in mice?
The mouse epidermal model demonstrates a skin-lineage requirement for Ash1l without establishing a universal skin phenotype in people with ASH1L-related neurodevelopmental disorder.
INTERPRETATION BOUNDARY
Read the finding and limit together.
What this study supports
Historically Yale-affiliated study showing an extra-neural role in epidermal differentiation, proliferation, and wound repair in mice.
What it cannot establish
Mouse epidermal biology does not establish a universal human skin phenotype in ASH1L-related NDD.
OPEN THE STUDY