COMPLETE CITATION
Citation and identifiers
Xia M, Liu J, Liu S, et al.. “ASH1L and lnc-Smad3 coordinate Smad3 locus accessibility to modulate iTreg polarization and T-cell autoimmunity.” Nature Communications. 8:15818 · doi:10.1038/ncomms15818.
- PubMed ID
- 28598443 ↗
RESEARCH QUESTION
How do ASH1L and lnc-Smad3 regulate Smad3 locus accessibility during induced regulatory T-cell polarization and autoimmunity?
The immune-model study identifies an Ash1l-dependent chromatin mechanism in induced regulatory T cells but does not demonstrate an immune phenotype in heterozygous ASH1L-related disorder.
INTERPRETATION BOUNDARY
Read the finding and limit together.
What this study supports
Supports an Ash1l-dependent chromatin mechanism in induced regulatory T-cell polarization and autoimmunity models.
What it cannot establish
Immune model evidence does not establish an immune phenotype in heterozygous ASH1L-related disorder.
OPEN THE STUDY