COMPLETE CITATION
Citation and identifiers
Huang C, Yang F, Zhang Z, et al.. “MRG15 stimulates ASH1L H3K36 methyltransferase activity.” Nature Communications. 8:16099 · doi:10.1038/s41467-017-01897-3.
- PubMed ID
- 29158494 ↗
RESEARCH QUESTION
Does MRG15 stimulate ASH1L H3K36 methyltransferase activity in biochemical and cellular systems?
The biochemical and structural evidence supports MRG15-dependent catalytic activation while leaving patient-specific dysfunction untested.
INTERPRETATION BOUNDARY
Read the finding and limit together.
What this study supports
Biochemical and structural work supporting MRG15-dependent activation of ASH1L methyltransferase activity.
What it cannot establish
Cofactor activation in purified and cellular systems does not establish patient-specific dysfunction.
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