COMPLETE CITATION
Citation and identifiers
Zhu L, et al.. “Histone methyltransferase Ash1L mediates activity-dependent repression of neurexin-1α.” Scientific Reports. 6:26597 · doi:10.1038/srep26597.
- PubMed ID
- 27229316 ↗
RESEARCH QUESTION
How does activity-dependent Ash1l recruitment affect Nrxn1α promoter chromatin and expression in mouse cortical neurons?
The one-locus neuronal model links Ash1l and H3K36me2 to activity-dependent Nrxn1α regulation without establishing fluctuating human cognition, regression, or treatment response.
INTERPRETATION BOUNDARY
Read the finding and limit together.
What this study supports
Shows activity-dependent recruitment of Ash1l and H3K36me2 at the Nrxn1α promoter in mouse cortical neurons.
What it cannot establish
One-locus in-vitro/model result; it does not establish fluctuating human cognition, regression, or treatment response.
OPEN THE STUDY