COMPLETE CITATION
Citation and identifiers
Yuan W, Xu M, Huang C, Liu N, Chen S, Zhu B. “H3K36 methylation antagonizes PRC2-mediated H3K27 methylation.” Journal of Biological Chemistry. 286(10):7983–7989 · doi:10.1074/jbc.M110.194027.
- PubMed ID
- 21239496 ↗
RESEARCH QUESTION
Does H3K36 methylation directly antagonize PRC2-mediated H3K27 methylation?
This mark-level biochemical result provides general chromatin context but does not show that ASH1L haploinsufficiency causes global Polycomb spreading or a uniform clinical state.
INTERPRETATION BOUNDARY
Read the finding and limit together.
What this study supports
Biochemical evidence that H3K36 methylation can directly inhibit PRC2-mediated H3K27 methylation.
What it cannot establish
Mark-level antagonism does not show that ASH1L haploinsufficiency produces global Polycomb spreading or a uniform human clinical state.
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