COMPLETE CITATION
Citation and identifiers
Bernstein BE, Mikkelsen TS, Xie X, et al.. “A bivalent chromatin structure marks key developmental genes in embryonic stem cells.” Cell. 125(2):315–326 · doi:10.1016/j.cell.2006.02.041.
- PubMed ID
- 16630819 ↗
RESEARCH QUESTION
How do bivalent H3K4me3 and H3K27me3 domains mark developmental genes in embryonic stem cells?
The study establishes bivalency as a general developmental-chromatin concept without demonstrating abnormal bivalent-domain resolution in ASH1L patient cells.
INTERPRETATION BOUNDARY
Read the finding and limit together.
What this study supports
Foundational evidence for H3K4me3/H3K27me3 bivalent domains that poise developmental regulators in embryonic stem cells.
What it cannot establish
Bivalency is a general developmental-chromatin concept. Its abnormal resolution has not yet been demonstrated broadly in ASH1L patient cells.
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