COMPLETE CITATION
Citation and identifiers
Pruitt A, Gupta AR, Hoffman EJ. “Molecular and genetic mechanisms in autism spectrum disorder.” Annals of Neurology. 98(6):1163–1177 · doi:10.1002/ana.70013.
- PubMed ID
- 40801227 ↗
RESEARCH QUESTION
Where does ASH1L fit within the chromatin and gene-regulation mechanisms reviewed for large-effect autism and neurodevelopmental risk genes?
This broad mechanistic review identifies ASH1L as a high-confidence chromatin and gene-regulation risk gene without supplying ASH1L-specific natural-history, phenotype, or intervention data.
INTERPRETATION BOUNDARY
Read the finding and limit together.
What this study supports
A Yale review of large-effect autism and NDD mechanisms that places ASH1L among high-confidence chromatin and gene-regulation risk genes.
What it cannot establish
Contextual synthesis rather than an ASH1L-specific phenotype, natural-history, or intervention study.
OPEN THE STUDY