COMPLETE CITATION
Citation and identifiers
Weinschutz Mendes H, Neelakantan U, Liu Y, et al.. “High-throughput functional analysis of autism genes in zebrafish identifies convergence in dopaminergic and neuroimmune pathways.” Cell Reports. 42(3):112243 · doi:10.1016/j.celrep.2023.112243.
- PubMed ID
- 36933215 ↗
RESEARCH QUESTION
How can a standardized multi-domain zebrafish pipeline be used to test convergence across autism-risk genes in future ASH1L work?
The study integrated morphology, behavior, brain activity, dopamine, and neuroimmune readouts across ten genes that did not include ASH1L, so its relevance is methodological only.
INTERPRETATION BOUNDARY
Read the finding and limit together.
What this study supports
A Yale-led standardized zebrafish pipeline across ten autism-risk genes, integrating morphology, sleep–wake behavior, sensorimotor response, whole-brain activity, dopaminergic measures, and neuroimmune readouts.
What it cannot establish
ASH1L was not one of the ten genes tested. This paper is included only as methodological context for the later Yale program and must not be cited as direct ASH1L evidence.
OPEN THE STUDY