COMPLETE CITATION
Citation and identifiers
Liu S, et al.. “ASH1L may contribute to risk of Tourette syndrome: combination of family-based analysis and case-control study.” Brain and Behavior. 12(4):e2539 · doi:10.1002/brb3.2539.
- PubMed ID
- 35307981 ↗
RESEARCH QUESTION
Do family-based and case-control analyses support an association between common ASH1L variants and Tourette syndrome?
The paper reports family transmission alongside a nonsignificant case-control result for common-variant risk, which must remain separate from rare pathogenic ASH1L loss-of-function disorder.
INTERPRETATION BOUNDARY
Read the finding and limit together.
What this study supports
Examines common-variant association with Tourette syndrome using family-based and case-control analyses.
What it cannot establish
The family transmission result and nonsignificant case-control result concern common-variant risk and must not be conflated with rare pathogenic ASH1L loss-of-function disorder.
OPEN THE STUDY