COMPLETE CITATION
Citation and identifiers
Miyazaki H, Higashimoto K, Yada Y, et al.. “ASH1L methylates Lys36 of histone H3 independently of transcriptional elongation to counteract Polycomb silencing.” PLOS Genetics. 9(11):e1003897 · doi:10.1371/journal.pgen.1003897.
- PubMed ID
- 24244179 ↗
RESEARCH QUESTION
How does ASH1L-mediated H3K36 methylation counteract Polycomb silencing during activation of selected developmental genes?
The differentiation models support a selected-locus mechanism for opposing Polycomb repression but do not demonstrate genome-wide spreading or failed bivalent-domain resolution in patient cells.
INTERPRETATION BOUNDARY
Read the finding and limit together.
What this study supports
ASH1L catalytic activity opposed Polycomb repression and supported timely activation of selected developmental genes in mouse differentiation systems.
What it cannot establish
Selected-locus model evidence; it does not establish genome-wide H3K27me3 spread or failed bivalent-domain resolution in human ASH1L patient cells.
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