COMPLETE CITATION
Citation and identifiers
Xia M, Liu J, Wu X, et al.. “Histone methyltransferase Ash1l suppresses IL-6 production and inflammatory autoimmune diseases by inducing the ubiquitin-editing enzyme A20.” Immunity. 39(3):470–481 · doi:10.1016/j.immuni.2013.08.016.
- PubMed ID
- 24012418 ↗
RESEARCH QUESTION
How does Ash1l restrain IL-6 production and inflammatory autoimmunity through A20 in macrophage and mouse models?
The Ash1l-A20 mechanism explains inflammatory control in macrophage and mouse systems without establishing a cytokine or immune phenotype in human ASH1L haploinsufficiency.
INTERPRETATION BOUNDARY
Read the finding and limit together.
What this study supports
Defines an Ash1l–A20/Tnfaip3 mechanism restraining inflammatory signaling in macrophage and mouse models.
What it cannot establish
Tissue- and model-specific; it does not establish a human cytokine or immune phenotype in ASH1L haploinsufficiency.
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