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Loss of histone methyltransferase ASH1L in the developing mouse brain causes autistic-like behaviors
Best match: How does developmental neural-lineage loss of Ash1l affect cortical development, myelination, cognition, and behavior in mice?How does developmental neural-lineage loss of Ash1l affect cortical development, myelination, cognition, and behavior in mice?
Open result Case profileClinical · Clinical · Case profilesNM_018489.3:c.6436C>T — Ages 1–5 ASH1L case profile
Best match: Brain MRI, sinus and mastoid findings, and sedationMidline structures, cerebral volume, myelination, morphology, pituitary appearance, and gray- and white-matter signal were age appropriate.
Open result PageBiology · BiologyWhere ASH1L has been experimentally perturbed—not merely detected.
Best match: Measure initiation, transition, closure, and recovery separately.NEURAL INTERFACE Neurons versus glia Compare maturation, excitability, transmitter and ion handling, metabolic support, myelination, and recovery after a defined challenge.
Open result PageBiology · BiologyTissue & cell biology
Human expression, direct cell and tissue experiments, state, timing, and experimental priorities.
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