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4 results for “H3K36me2”

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Page · Resources

Plain-language glossary

Best match: The words should help—not become another barrier.

H3K36 Also searched as: histone H3 lysine 36 · H3K36 methylation · H3K36me2 A position on histone H3 that can carry methyl marks involved in chromatin regulation; ASH1L has H3K36 methyltransferase activity in experimental systems.

Open result →Page · Biology

Tissue & cell biology

Best match: Where ASH1L has been experimentally perturbed—not merely detected.

, 2022 ↗ 13 Heart development Drosophila cardiac tissue Distal in vivo model WHAT THE EXPERIMENT ESTABLISHES Ash1 with Caf1-55 and MRG15 supported H3K36me2-dependent heart development in vivo.

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Evidence library

Best match: 2016 Histone methyltransferase Ash1L mediates activity-dependent repression of neurexin-1α Zhu L, et al. · Scientific Reports Peer reviewed

Why it matters here: The one-locus neuronal model links Ash1l and H3K36me2 to activity-dependent Nrxn1α regulation without establishing fluctuating human cognition, regression, or treatment response.

Open result →Page · Biology

Gene & biology

Best match: Primary mechanistic evidence

…models H3K36-modified nucleosomes and selected Ash1l-dependent loci H3K36me2/3 on the same nucleosome inhibited PRC2 H3K27 methylation; Ash1l opposed Polycomb at selected loci.

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