The histone methyltransferase ASH1L protects against bone loss by inhibiting osteoclastogenesis
Cell Death & Differentiation
Which extra-neural tissues have direct evidence?
Open citation, findings, and limits →EVIDENCE LIBRARY
Start with the research question. Then judge the evidence type.
Each of the 50 publications has a paper-specific research question and explanation of its limits. Human, cellular, in-vivo, molecular, extra-neural, and synthesis evidence remain distinct. Open any study to read its findings and limits together.
READING STANDARD
Start with the question each study can answer.
Human studies define association and phenotype. Cellular and in-vivo models test mechanism within a specific perturbation. Molecular studies define protein behavior. Context sources inform methods without becoming direct ASH1L evidence. The downloadable data explains why each source matters for the question being asked.
START WITH THE RESEARCH QUESTION
What are you trying to establish?
Each of the 50 publications is paired with one primary question and one evidence type.
EVIDENCE TYPE
Extra-neural model systems
Ash1L ameliorates psoriasis via limiting neuronal activity-dependent release of miR-let-7b
British Journal of Pharmacology
Which extra-neural tissues have direct evidence?
Open citation, findings, and limits →H3K36 Di-Methylation Marks, Mediated by Ash1 in Complex with Caf1-55 and MRG15, Are Required during Drosophila Heart Development
Journal of Cardiovascular Development and Disease
Which extra-neural tissues have direct evidence?
Open citation, findings, and limits →ASH1L contributes to oocyte apoptosis by regulating DNA damage
American Journal of Physiology–Cell Physiology
Which extra-neural tissues have direct evidence?
Open citation, findings, and limits →The Trithorax protein Ash1L promotes myoblast fusion by activating Cdon expression
Nature Communications
Which extra-neural tissues have direct evidence?
Open citation, findings, and limits →The histone methyltransferase Ash1l is required for epidermal homeostasis in mice
Scientific Reports
Which extra-neural tissues have direct evidence?
Open citation, findings, and limits →ASH1L and lnc-Smad3 coordinate Smad3 locus accessibility to modulate iTreg polarization and T-cell autoimmunity
Nature Communications
Which extra-neural tissues have direct evidence?
Open citation, findings, and limits →ASH1L controls quiescence and self-renewal potential in hematopoietic stem cells
Journal of Clinical Investigation
Which extra-neural tissues have direct evidence?
Open citation, findings, and limits →Histone methyltransferase Ash1l suppresses IL-6 production and inflammatory autoimmune diseases by inducing the ubiquitin-editing enzyme A20
Immunity
Which extra-neural tissues have direct evidence?
Open citation, findings, and limits →AUTHORITATIVE DATABASES & RESEARCH RESOURCES
Use the live databases for current gene and variant records.
Database records change as laboratories submit evidence and expert panels update curation. Review transcript, condition, classification, review status, submitter, and date together.
GENE-DISEASE & DOSAGEClinGen — ASH1L
Expert-curated validity and dosage sensitivity.
Open ↗EXTERNAL VARIANT SOURCESExternal variant sourcesPublished variant sources, mapped protein positions, source links, and privacy boundaries.
Review →GENE REFERENCENCBI Gene — ASH1LIdentifiers, transcripts, expression, domains, and linked literature.
Open ↗VARIANT ARCHIVEClinVar — ASH1LSubmitted classifications with review status and condition context.
Open ↗AUTISM GENETICSSFARI Gene — ASH1LCurated human genetics and model-system evidence for ASH1L.
Open ↗LIVE LITERATURE SEARCHPubMed — ASH1LThe current indexed publication search beyond this library.
Open ↗FAMILY RESEARCHSimons Searchlight — ASH1LResearch participation and family-facing gene information.
Open ↗RECOMMEND A SOURCE
Suggest a paper for review.
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